Beware (Non-Proportional) Hazard! Alternative Routes for Dealing with Time-Varying Treatment Effects in Evidence Synthesis for Health Technology Assessment (HTA) Decision Making

About this session

ISSUE: Often when conducting meta-analyses (MA) of time-to-event (TTE) results, especially in Health Technology Assessment (HTA), a hazard ratio (HR) scale is used due to the ease with which a treatment effect can be incorporated into a cost-effectiveness decision model. However, issues arise when there is evidence of non-proportional hazards in some of the trials/studies included.

Speakers

• 

  Keith R Abrams

  University of Warwick

  Moderator

• DP

  David Phillippo

  University of Bristol

  Panelist

• RO

  Rhiannon K Owen

  Swansea University

  Panelist

• 

  Shannon Cope

  Unpuzzle HEOR, VANCOUVER

  Panelist